银叶树内生黑孢菌HU0460抗细菌活性成分研究Antibacterial Metabolites of Endophytic Nigrospora sp. HU0460 from Heritiera littoralis
叶玉珍;钟志娟;李馨;钟富丹;黄钰涵;毛露甜;徐良雄;
摘要(Abstract)：
植物内生真菌次生代谢产物资源丰富，是发现新型抗生素的重要来源。在活性追踪的指导下，从银叶树内生黑孢菌HU0460的玉米发酵物中分离鉴定了4个蒽醌类化合物，分别为化合物（1、2、3和4）:4a-epi-4β,9α-dimethoxydihydrodeoxybostrycin(1)、4a--epi--9α-methoxydihydrodeoxybostrycin(2)、9α-hydroxyhalorosellinia A(3)和bostrycin(4)，其中第1个为新化合物。化合物4对金黄色葡萄球菌、黑胫病菌和青枯病菌的抗菌活性较高，其MIC分别为25、50和12.5μg/mL，其余3个化合物对上述测试菌表现出较弱的抑制活性，所有化合物对大肠杆菌无明显的抑制活性。研究结果初步阐明该菌的抗菌活性物质基础，对黑孢菌属抗菌成分的深入研究与开发方面具有一定的参考价值。
关键词(KeyWords)： 黑孢菌属;蒽醌;分离纯化;抗细菌活性
基金项目(Foundation): 国家自然科学基金项目（31772032）;; 广东省大学生创新训练项目（S202110577048）;; 广东省科技创新战略专项资金项目（pdjh202160481）
作者(Authors): 叶玉珍;钟志娟;李馨;钟富丹;黄钰涵;毛露甜;徐良雄;
DOI: 10.16778/j.cnki.1671-5934.2022.06.007
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